| Week | Topic(s) |
| Week 1 | History, importance & applications of computational biology & bioinformatics. |
| Week 2 | Biological data, importance of biological databases & their biological design basis, file formats & types (primary, secondary, sequence, structure & other), information retrieval from various biological databases, databases of nucleic acids sequence & structure, protein sequence & structure, chemical structures, biological networks & metabolic pathways, biomedical image databases. |
| Week 3 | Practical importance of biological databases in different segments of healthcare, pharmaceutical and biotech industries |
| Week 4 | Practical importance of aligning two or more than 2 genes/ genome sequences, Biological sequences alignment principles, its importance & applications, different alignment techniques (dot matrix, dynamic programming, heuristics), scoring matrices (BLOSUM & PAM), gaps, global versus local sequence |
| | alignment |
| Week 5 | Pairwise sequence alignment & its methods, tools of similarity searches (BLAST, PSI-BLAST), multiple sequence alignment (practical issues, methods & tools: Clustal Omega, TCoffee, MUSCLE) |
| Week 6 | Introduction, need for genome mining, applications including natural product biosynthesis. Case studies and future directions. |
| Week 7 | Introduction & importance, DNA structure prediction method, secondary structure of RNA, methods of RNA secondary structure prediction & tools. |
| Week 8 | Protein structural hierarchy, super secondary structures, structure determination, protein folding, sequence structure relation, methods of protein secondary structure prediction (ab initio modeling, threading, homology modeling), structure evaluation, protein structure visualization tools, structure function relation, protein function prediction, motifs & domains. |
| Week 9 | Introduction, importance & applications of patterns, motifs, and profiles, PROSITE, BLOCKS, PRINTS, Pfam. How to utilize RNA/Protein structures in drug designing and discovery with case studies of commercial importance. |
| Week 10 | Importance & applications, methods of phylogenetic analysis (distance & character based) |
| Week 11 | Phylogenetic tree construction & topologies, tools for tree visualization |
| Week 12 | Computer aided drug design and development, drug design approaches, ligand-based drug design, structure-based drug design |
| Week 13 | Chemical compound structure prediction, ADMET Prediction, computational vaccine design (antigen-antibody interactions) |
| Week 14 | Computer models of population dynamics, biochemical kinetics, cell pathways, etc. Morphological image analysis, image classification and image-derived models for use in clinical decision support systems |